---
title: Recovery of the Pupillary Response After Light Adaptation is Slowed in Patients with Age-Related Macular Degeneration
description: Peer-reviewed study in the Journal of Eye Movement Research reports that recovery of the pupillary response after light adaptation is slower in patients with age-related macular degeneration than in healthy controls, using a VR headset with integrated eye tracking
---

[News](https://www.machinemd.com/news)

# [Recovery of the Pupillary Response After Light Adaptation is Slowed in Patients with Age-Related Macular Degeneration](https://www.machinemd.com/news/pupillary-light-response-amd)

 Written by [machineMD](https://www.machinemd.com/news/author/machinemd) | Nov 11, 2025

Peer-reviewed results show that recovery of the pupillary response after light adaptation is significantly slowed in AMD, reinforcing the potential of oculometrics for clinical research and drug development.

 

machine**MD** collaborated with the University Hospital Zurich and Berner Augenklinik to study the *Recovery of the Pupillary Response After Light Adaptation*, finding that it *Is Slowed in Patients with Age-Related Macular Degeneration.* 

 

This proof-of-concept study demonstrates that consumer-grade VR headsets with integrated eye tracking can detect retinal dysfunction associated with AMD. The method offers a fast, accessible, and potentially scalable approach for retinal disease screening and monitoring. This underscores the role of oculometrics as complementary functional measures in retinal research and clinical trials.

 

**Why this matters in AMD:**

- **Objective physiology:** Quantitative readouts that do not rely on subjective responses
- **Multi-center consistency:** Standardized stimulus protocols suited for site-to-site reproducibility
- **Trial utility:** A promising avenue to explore functional biomarkers and endpoint candidates alongside imaging.

**Read the publication**  
Open access: [https://doi.org/10.3390/jemr18060066](https://doi.org/10.3390/jemr18060066) <https://www.mdpi.com/1995-8692/18/6/66>

 

**Partner with us**  
Pharma and biotech teams exploring AMD endpoints or digital biomarkers: contact us using the below form to discuss protocol integration and pilot studies.

 

[View full post](https://www.machinemd.com/news/pupillary-light-response-amd)

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